Human brain models in vitro
Neuronal and tumourigenic boundaries of glioblastoma plasticity
De Silva MI, Stringer B, Bardy C
Trends in Cancer (2022) (in press)
Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons
van den Hurk M , Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, Winner B, Winkler J, Gage FH, Bardy C
npj Parkinson's Disease (2022) (8):134
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients
Stern S … Bardy C, Brice A, Winkler J, Marchetto MC, Gage FH
npj Parkinson's Disease (2022) (8):103
Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings.
Milky B, Zabolocki M, Al-Bataineh SA, Hurk M van den, Greenberg Z, Turner L, Mazzachi P, Williams A, Illeperuma I, Adams R, Stringer BW, Ormsby R, Poonnoose S, Smith LE, Krasowska M, Whittle JD, Simula A, Bardy C
Stem Cell Reports (2022)
Modeling the human brain with ex vivo slices and in vitro organoids for translational neuroscience
Nogueira GO, Garcez PP, Bardy C, Cunningham MO, Sebolela A.
Frontiers in Neuroscience (2022)
Patch-seq: Past, Present, and Future
Lipovsek M, Bardy C, Cadwell CR, Hadley K, Kobak D, Tripathy SJ.
Journal of Neuroscience (2021)
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro
Zabolocki M, McCormack K, van den Hurk M, Milky B,
Shoubridge AP, Adams R, Tran J, Mahadevan-Jansen A, Reineck P, Thomas J, Hutchinson MR, Mak CKH, Añonuevo A, Chew LH, Hirst AJ, Lee VM, Knock E, Bardy C
Nature Communications (2020) 11, 5550
Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells
Tran J, Anastacio H, Bardy C
npj Parkinson's Disease (2020) 6:8
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.
Ebert LM, Yu W, Gargett T, Toubia J, Kollis PM, Tea MN, et al. Clinical & Translational Immunology (2020); 9(10):506
Retromer regulates the lysosomal clearance of MAPT/TAU
Carosi M, Hein LK, van den Hurk M, Adams R, Milky B, Singh S, Bardy C, Denton D, Kumar S, Sargeant TJ
Personalized psychiatry with human iPSCs and neuronal reprogramming.
Bardy C, Greenberg, Z, Perry SW, Licinio J.
Personalized Psychiatry - ELSEVIER - 1st edition - Editor: Bernhard Baune. (2020) pp. 127-146
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis
Jin X, Xie J, Zabolocki M, Wang X, Jiang T, Wang D, Desaubry L, Bardy C, Proud CG
Journal of Biological Chemistry (2020)
Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models.
Hurk MVD and Bardy C.
Journal of Neuroscience Methods (2019) 325:108350
Patch-seq protocol to analyze the electrophysiology, morphology and transcriptome of whole single neurons derived from human pluripotent stem cells.
Hurk MVD, Erwin JA, Yeo GW, Gage FH, Bardy C.
Frontiers in Molecular Neuroscience (2018) 11: 261
Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs
Strnadel J, Carromeu C, Bardy C, et al.. Marsalla M.
Science Translational Medicine (2018) 10: eaam6651
Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro
Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH.
Cell Stem Cell (2018) 22: 684–697.e9
Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids.
Oksdath M, Perrin SL, Bardy C, Hilder EF, DeForest CA, Arrua DR, Gomez GA.
APL Bioengineering (2018) 2: 041501
Predicting the functional states of human neurons with single-cell RNA-seq and electrophysiology
Bardy C, Hurk MVD, Kakaradov B, Erwin J, Jaeger B, Hernandez RV, Eames T, Gorris M, Paucar A, Jappeli R, Barron J, Marchand C, Bryant A, Kellogg M, Lasken R, Rutten B, Steinbush H, Yeo G, Gage FH
Molecular Psychiatry (2016) - Download PDF
A human neurodevelopmental model for Williams syndrome
Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MCN, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard CM, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Belui U, Halgren E, Semendeferi K & Muotri AR
Evaluating cell reprogramming differentiation and conversion technologies in neuroscience
Mertens J, Marchetto C, Bardy C and Gage FH.
Nature Reviews Neuroscience (2016)
Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency
van den Hurk M, Kenis G, Bardy C, van den Hove DLA, Gage FH, Steinbusch HWM and Rutten BPF
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration
Zheng X, Boyer L, Jim M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T.
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
Bardy C., Van den Hurk M., Eames T., Marchand C., Hernandez RV., Kellogg M., Gorris M., Galet B., Palomares V., Brown J., Bang AG., Mertens J., Bohnke, L., Boyer L., Simon S., Gage FH.
PNAS (2015) - Download PDF
see comment in Reconstructing neuronal milieu. Livesey, PNAS 2015
Generation of functional human serotonergic neurons from fibroblasts
Krishna C. Vadodaria*, Jerome Mertens*, Apua Paquola, Cedric Bardy, Roberto Jappelli, Lianna Fung, Michael Hamm, Marc Gorris, and Fred H. Gage
Molecular Psychiatry (2015)
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
Israel MA., Yuan SH, Bardy C., Reyna SM., Mu Y., Herrera C., Hefferan MP., Van Gorp S., Nazor KL, Boscolo FS, Carson CT., Laurent LC., Marsala M., Gage FH., Remes AM., Koo EH. & Goldstein LSB.
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Giorgetti, A. et al.
Activation of adult-born neurons facilitates learning and memory.
Alonso, M., Lepousez, G., Wagner, S., Bardy, C., Gabellec, MM., Torquet, N. & Lledo, PM.
Nature Neuroscience (2012).
How, when, and where new inhibitory neurons release neurotransmitters in the adult olfactory bulb.
Bardy, C., Alonso, M., Bouthour, W., & Lledo, PM.
The Journal of Neuroscience (2010). Download PDF
What happens to olfaction without adult neurogenesis.
Bardy, C., & Pallotto, M.
Frontiers in Neuroscience (2010).
Adult neurogenesis promotes synaptic plasticity in the olfactory bulb.
Nissant, A., Bardy, C., Katagiri, H., Murray, K., & Lledo, PM.
Nature Neuroscience (2009).
Early synapse formation in developing interneurons of the adult olfactory bulb.
Panzanelli, P., Bardy, C., Nissant, A., Pallotto, M., Sassoe-Pognetto, M., Lledo, PM., & Fritschy, J.
The Journal of Neuroscience (2009).
Cortical circuits in vivo
'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and “feedback” inactivation.
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B.
The Journal of Physiology (2006).
'Top-down‘ influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat’s striate cortex.
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B.
Contrast dependence of center and surround integration in primary visual cortex of the cat.
Wang, C., Bardy, C., Huang, J. Y., FitzGibbon, T., & Dreher, B.
Journal of Vision (2009).
Influence of “feedback” signals on spatial integration in receptive fields of cat area 17 neurons.
Wang, C., Huang, J. Y., Bardy, C., FitzGibbon, T., & Dreher, B.
Brain Research (2010).
Modulatory effect of substance P to the brain stem locomotor command in lampreys.
Brocard, F., Bardy, C., & Dubuc, R.
Journal of Neurophysiology (2005).
Cedric Bardy's short biography:
Associate Professor Cedric Bardy is neurobiologist with in-depth expertise in human neural stem cell models, electrophysiology and single cell transcriptomics. His research efforts are focused on advancing new stem cell biotechnologies and strategies to understand the effect of neurological disorders on brain cells.
Cedric grew up in the South of France before moving to Australia to obtain a PhD in Medicine from the University of Sydney (2008). He pursued his postdoctoral training in Neuroscience in the laboratory of Prof. Pierre-Marie Lledo at the Pasteur Institute in Paris (2008-2010). He then received the prestigious Marie Curie International Fellowship to continue his research in California at the Salk Institute in California under the mentorship of Prof. Fred Gage (2011-2016).
At the end of 2016, he was recruited back to Australia by SAHMRI and Flinders University, where he established a new research program aiming to improve pre-clinical translation in neurology. In January 2021, he was promoted to Associate Professor by Flinders University. He currently leads the Laboratory for Human Neurophysiology and Genetics located at SAHMRI.
Cedric has contributed to pioneering the development of iPSC models to study brain disorders. In particular, he is the inventor of BrainPhys, a neuronal medium broadly used to culture and mature human neurons in vitro, and he co-authored the first iPSC paper of Alzheimer’s published in Nature.