Human IPSC-derived neuronal models in vitro

Predicting the functional states of human neurons with single-cell RNA-seq and electrophysiology
Bardy C, Hurk MVD, Kakaradov B, Erwin J, Jaeger B, Hernandez RV, Eames T, Gorris M, Paucar A, Jappeli R, Barron J, Marchand C, Bryant A, Kellogg M, Lasken R, Rutten B, Steinbush H, Yeo G, Gage FH
Molecular Psychiatry (2016) in press 

A human neurodevelopmental model for Williams syndrome
Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX,  Brown TT, Marchetto MCN, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard CM, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Belui U, Halgren E, Semendeferi K & Muotri AR
Nature (2016), in press 

Evaluating cell reprogramming differentiation and conversion technologies in neuroscience
Mertens J, Marchetto C, Bardy C and Gage FH. 
Nature Reviews Neuroscience (2016) 

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency
van den Hurk M, Kenis G, Bardy C, van den Hove DLA, Gage FH, Steinbusch HWM and Rutten BPF 
Epigenomics (2016) 

Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration
Zheng X, Boyer L, Jim M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T. 
Elife (2016)

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
Bardy, C., Van den Hurk, M., Eames, T., Marchand, C., Hernandez, R.V., Kellogg, M., Gorris, M., Galet, B., Palomares, V., Brown, J., Bang, A.G., Mertens, J., Bohnke, L., Boyer, L., Simon, S., Gage, F.H. 
PNAS (2015)

Generation of functional human serotonergic neurons from fibroblasts
Krishna C. Vadodaria*, Jerome Mertens*, Apua Paquola, Cedric Bardy, Roberto Jappelli, Lianna Fung, Michael Hamm, Marc Gorris, and Fred H. Gage 
Molecular Psychiatry (2015)

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
C., Reyna, S. M., Mu, Y., Herrera, C., Hefferan, M. P., Van Gorp, S., Nazor, K.L, Boscolo, F.S, Carson, C.T., Laurent, L.C., Marsala, M., Gage, F.H., Remes, A.M., Koo, E.H. & Goldstein, L.S.B. 
Nature (2012)

Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. 
Giorgetti, A. et al. 
PNAS (2012)

Neurogenesis
Activation of adult-born neurons facilitates learning and memory. 
Alonso, M., Lepousez, G., Wagner, S., Bardy, C., Gabellec, MM., Torquet, N. & Lledo, PM. 
Nature Neuroscience (2012).

How, when, and where new inhibitory neurons release neurotransmitters in the adult olfactory bulb. 
Bardy, C., Alonso, M., Bouthour, W., & Lledo, PM.  
The Journal of Neuroscience (2010).

What happens to olfaction without adult neurogenesis. 
Bardy, C., & Pallotto, M. 
Frontiers in Neuroscience (2010).

Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. 
Nissant, A., Bardy, C., Katagiri, H., Murray, K., & Lledo, PM.  
Nature Neuroscience (2009).

Early synapse formation in developing interneurons of the adult olfactory bulb. 
Panzanelli, P., Bardy, C., Nissant, A., Pallotto, M., Sassoe-Pognetto, M., Lledo, PM., & Fritschy, J. 
The Journal of Neuroscience (2009).


Cortical circuits

'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and “feedback” inactivation. 
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B. 
The Journal of Physiology  (2006).

'Top-down‘ influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat’s striate cortex. 
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B. 
Neuroscience (2009). 

Contrast dependence of center and surround integration in primary visual cortex of the cat. 
Wang, C., Bardy, C., Huang, J. Y., FitzGibbon, T., & Dreher, B.  
Journal of Vision (2009).

Influence of “feedback” signals on spatial integration in receptive fields of cat area 17 neurons.
Wang, C., Huang, J. Y., Bardy, C., FitzGibbon, T., & Dreher, B. 
Brain Research (2010).

Modulatory effect of substance P to the brain stem locomotor command in lampreys.
Brocard, F., Bardy, C., & Dubuc, R. 
Journal of Neurophysiology (2005).